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Decoy Nanoparticles Provide protection to In opposition to COVID-19 by Adsorbing Both Viruses and Inflammatory Cytokines

Cytokine Storms and T Cells Illustration

Researchers file the come of cell membrane nanovesicles that elevate receptors for SARS-CoV-2 and diversified inflammatory cytokines on their surfaces, thereby acting as decoys for every SARS-CoV-2 and inflammatory cytokines; the decoy nanoparticles inhibited infection by SARS-CoV-2 and neutralized inflammatory cytokines in vitro, and diminished lung damage in a mouse mannequin of acute lung irritation, suggesting that they would possibly perhaps well be a doable therapeutic plot for COVID-19, in accordance with the authors.

Significance

The COVID-19 pandemic triggered by SARS-CoV-2 infection has resulted in extra than 840,000 deaths worldwide as of August 31, 2020. Sadly, no licensed vaccine or particular medication is available lawful now. Herein, we file a decoy nanoparticle against COVID-19. The decoy nanoparticles had been constructed by fusing cell membrane nanovesicles derived from genetically engineered cells, which stably insist SARS-CoV-2 receptor ACE2, and human monocytes, which keep abundant cytokine receptors. By competing with host cells, these nanodecoys efficiently adsorb viruses and inflammatory cytokines equivalent to IL-6 and GM-CSF. These two functionalities allow efficient intervention of viral infection and its associated immune dysfunction, presenting a promising therapeutic plot for COVID-19 and other doable epidemics.

Abstract

The COVID-19 pandemic, triggered by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has highlighted the urgent must fleet hold therapeutic programs for such rising viruses with out efficient vaccines or medication. Here, we file a decoy nanoparticle against COVID-19 by a highly efficient two-step neutralization device: virus neutralization in the critical step followed by cytokine neutralization in the 2nd step. The nanodecoy, made by fusing cell membrane nanovesicles derived from human monocytes and genetically engineered cells stably expressing angiotensin converting enzyme II (ACE2) receptors, possesses an antigenic exterior the equal as source cells. By competing with host cells for virus binding, these nanodecoys effectively give protection to host cells from the infection of pseudoviruses and educated SARS-CoV-2. Moreover, counting on abundant cytokine receptors on the floor, the nanodecoys efficiently bind and neutralize inflammatory cytokines including interleukin 6 (IL-6) and granulocyte−macrophage colony-stimulating component (GM-CSF), and drastically suppress immune dysfunction and lung damage in an acute pneumonia mouse mannequin. Our work presents a straightforward, stable, and strong antiviral nanotechnology for ongoing COVID-19 and future doable epidemics.

Reference: “Decoy nanoparticles give protection to against COVID-19 by similtaneously adsorbing viruses and inflammatory cytokines” by Lang Rao, Shuai Xia, Wei Xu, Rui Tian, Guocan Yu, Chenjian Gu, Pan Pan, Qian-Fang Meng, Xia Cai, Di Qu, Gape ORCID ProfileLu Lu, Youhua Xie, Shibo Jiang and Xiaoyuan Chen, 6 October 2020, Court cases of the Nationwide Academy of Sciences.

DOI: 10.1073/pnas.2014352117

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