Sunday, October 25News That Matters

Roche Canada publicizes FoundationOne® Liquid CDx now readily available in Canada

Complete pan-tumour liquid biopsy test analyzes >300 cancer-related genes and 2 genomic signatures to articulate treatment picks

MISSISSAUGA, ON, Sept. 8, 2020 /CNW/ – Hoffmann-La Roche Dinky (Roche Canada) this present day announced that FoundationOne® Liquid CDx, Foundation Remedy’s comprehensive pan-tumour liquid biopsy test for patients with trusty tumours, is now readily available in Canada.

FoundationOne Liquid CDx is a comprehensive genomic profiling (CGP) test that analyzes >300 cancer-related genes and 2 genomic signatures to articulate the use of focused oncology therapies, including immunotherapies. The utilization of a straightforward blood design, the test permits extra patients with stepped forward cancer to profit from the insights of comprehensive genomic profiling, when a tissue biopsy isn’t likely, suggested or can even be safely modified.

In 2020, 225,800 Canadians are expected to be identified with cancer— a illness of the genome, driven by genetic mutations within a tumour’s DNA.2 Complete Genomic Profiling (CGP) can even be worn to name these unfamiliar mutations to value how a tumour behaves and grows, and these insights can abet physicians to resolve a personalized treatment plot for each and every particular person patient in accordance with the explicit mutations identified.3,4,5,6,7

“This test brings us nearer to a precision formulation to cancer treatment for all of our patients,” acknowledged Dr. Natasha Leighl, Professor of Remedy at the College of Toronto and Scientific Oncology Lung Location Lead at Princess Margaret Cancer Centre. “Liquid biopsies personal transformed our skill to diagnose and produce optimum treatment plans for our patients thru a blood test rather then an invasive tumour biopsy.”

The utilization of a blood pattern, FoundationOne Liquid CDx analyzes over 300 cancer-related genes for alterations. FoundationOne Liquid CDx outcomes are delivered in an constructed-in mumble that identifies alterations matched to US FDA-permitted therapies and, within its skilled services share, delivers files in regards to the genomic signatures microsatellite instability and blood tumor mutational burden, as well to single gene alterations, including all NTRK fusions, to abet articulate the use of different therapies including immunotherapies. The mumble moreover offers related medical trial files and entails interpretive converse material developed in accordance with skilled pointers in oncology for patients with any trusty tumor.

“On this technology of precision medication, the molecular profile of a patient’s particular person tumour can abet them and their medical physique of workers draw distinguished treatment choices,” acknowledged Shem Singh, Govt Director Lung Cancer Canada. “Blood based sorting out solutions equivalent to FoundationOne Liquid CDx are non-surgical ideas that can provide patients with this files, serving to us switch in direction of in actual fact customized medication.”

FoundationOne Liquid CDx is basically the most modern addition to Foundation Remedy’s portfolio of excessive-quality CGP tests. Collectively, the excessive-quality FoundationOne Liquid CDx and FoundationOne CDx genomic profiling tests personal the aptitude to abet enhance patient outcomes by helping oncologists to optimize and personalize treatment approaches for their patients with stepped forward cancer, at some level of all traces of treatment.

For added facts about FoundationOne Liquid CDx, please take a look at with:

About FoundationOne® Liquid CDx

FoundationOne Liquid CDx is a subsequent-technology sequencing provider that analyzes 324 genes. Substitutions and insertion and deletion alterations (indels) are reported in 311 genes; reproduction quantity alterations and gene rearrangements are reported in have out genes. FoundationOne Liquid CDx makes use of circulating cell-free DNA isolated from plasma derived from anti-coagulated peripheral complete blood of cancer patients. FoundationOne Liquid CDx is intended to form tumour mutation profiling to be worn by licensed health care experts in accordance with skilled pointers in oncology for patients with malignant neoplasms. FoundationOne Liquid CDx is a single-plot assay performed at Foundation Remedy Inc. laboratories located in Cambridge Massachusetts, USA. Hoffmann-La Roche Dinky markets these services in Canada below an unique license.

About Roche

Roche is a global pioneer in prescribed medication and diagnostics taking into consideration advancing science to bolster other folk’s lives. The combined strengths of prescribed medication and diagnostics

below one roof personal made Roche the chief in customized healthcare – a approach that objectives to suit the correct treatment to each and every patient in the simplest approach likely.

Roche is the sphere’s ideal biotech firm, with in actual fact differentiated medicines in oncology, immunology, infectious ailments, ophthalmology and ailments of the central apprehensive machine. Roche is moreover the sphere chief in in vitro diagnostics and tissue-based cancer diagnostics, and a frontrunner in diabetes management.

Founded in 1931, Roche Canada is dedicated to shopping higher ways to live, diagnose and treat ailments whereas making a sustainable contribution to society. The firm employs extra than 1,200 other folk across the nation thru its Pharmaceuticals division in Mississauga, Ontario and Diagnostics, as well to Diabetes Care divisions in Laval, Quebec.

Roche objectives to bolster patient discover admission to to medical innovations by working with all related stakeholders. Roche Canada is actively angry about native communities thru its charitable giving and partnerships with organizations and healthcare institutions that work together to bolster the usual of existence of Canadians. For added files, please take a look at with

All replace-marks talked about are the property of their respective homeowners.

© Copyright 2020; Hoffmann-La Roche Dinky


1 Canadian Cancer Society. 6 statistics that exhibit the influence of cancer in Canada for 2020. On hand at: [Accessed June 2020].

2 Canadian Cancer Society. Genes and cancer. [Accessed June 2020].

3 Brenner DR et al. Projected estimates of cancer in Canada in 2020. CMAJ 2020 March 2;192:E199-205. doi: 10.1503/cmaj.191292

4 Hirshfield KM, Tolkunov D, Zhong H, et al. Scientific Actionability of Complete Genomic Profiling for Management of Uncommon or Refractory Cancers. Oncologist. 2016;21(11): 1315-1325. doi: 10.1634/theoncologist.2016-0049

5 Rankin A, Klempner SJ, Erlich R, et al. Gargantuan Detection of Alterations Predicted to Confer Lack of Merit From EGFR Antibodies or Sensitivity to Targeted Remedy in Progressed Colorectal Cancer. Oncologist. 2016;21(11): 1306-1314. doi: 10.1634/theoncologist.2016-0148

6 Batlevi, C, Moskowitz, C. H, Zelenetz, A. D, et al. Identification of Actionable Genomic Alterations Across Utterly different Lymphoma Histologies The utilization of a Complete Subsequent Generation Genomic Sequencing Scientific Assay. Blood, 124(21), 3000-3000. doi: 10.1182/blood.v124.21.3000.3000

7 Suh JH, Johnson A, Albacker L, et al. Complete Genomic Profiling Facilitates Implementation of the Nationwide Complete Cancer Community Pointers for Lung Cancer Biomarker Making an strive out and Identifies Sufferers Who Can also Merit From Enrollment in Mechanism-Driven Scientific Trials. Oncologist. 2016;21(6): 684-691. doi: 10.1634/theoncologist.2016-0030

SOURCE Hoffmann-La Roche Dinky (Roche Canada)

For added files: Bridget Wells, Roche Canada, T: 905-542-5072; Sydney Dubin, Proof Methods, T: 416-969-2816

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